OAZ2 rabbit pAb

OAZ2 rabbit pAb

Item number: ES9963
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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OAZ2 rabbit pAb

OAZ2 rabbit pAb

$148.00

OAZ2 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
20kD
Geneid human
4947
Human swiss prot no
O95190
Cellular localization
Nucleus .
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different sub

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