11β-HSD1 rabbit pAb

11β-HSD1 rabbit pAb

Item number: ES4290
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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11β-HSD1 rabbit pAb

11β-HSD1 rabbit pAb

$148.00

11β-HSD1 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
Synthesized peptide derived from 11β-HSD1 . at AA range: internal
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
35kD
Geneid human
3290
Human swiss prot no
P28845
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
hydroxysteroid 11-beta dehydrogenase 1(HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011],

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