1C04 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES18543
Regular price
$148.00 USD
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Regular price
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB
Cellular localization
ane,extracellular region,endoplasmic reticulum,atus,plasma membrane,integral component of plasma membrane,cell surface,ER to port vesicle membrane,membrane,integral component of membrane,phaicle membrane,early endosome membrane,MHC class I protein complex,MHC class II protein complex,extracellular exosome,integral component of lumenal side of endoplasmic reticulum membrane,
Clonality
Polyclonal
Concentration
1 mg/ml
Human swiss prot no
P30504
Immunogen
Synthesized peptide derived from human 1C04 AA range: 110-160
Isotype
IgG
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Recommended dilutions
WB 1：500-2000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008],
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Product Citations
More Info
More Info
1C04 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
