20S Proteasome α3 (phospho Ser250) rabbit pAb

Name: 20S Proteasome α3 (phospho Ser250) rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES6856

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;IHC;IF;ELISA

Cellular localization

Cytoplasm . Nucleus . Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

5684

Human swiss prot no

P25788

Immunogen

The antiserum was produced against synthesized peptide derived from human Proteasome alpha3 around the phosphorylation site of Ser250. AA range:206-255

Isotype

IgG

Observed band

32kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Source

Rabbit

Storage

-20°C/1 year

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

20S Proteasome α3 (phospho Ser250) rabbit pAb

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