20S Proteasome α3 (phospho Ser250) rabbit pAb

20S Proteasome α3 (phospho Ser250) rabbit pAb

Item number: ES6856
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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20S Proteasome α3 (phospho Ser250) rabbit pAb

20S Proteasome α3 (phospho Ser250) rabbit pAb

$148.00

20S Proteasome α3 (phospho Ser250) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Proteasome alpha3 around the phosphorylation site of Ser250. AA range:206-255
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
32kD
Geneid human
5684
Human swiss prot no
P25788
Cellular localization
Cytoplasm . Nucleus . Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. .
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

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