3HAO rabbit pAb

3HAO rabbit pAb

Item number: ES9308
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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3HAO rabbit pAb

3HAO rabbit pAb

$148.00

3HAO rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
31kD
Geneid human
23498
Human swiss prot no
P46952
Cellular localization
Cytoplasm, cytosol .
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008],

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