A-366

Vendor: Abmole

Type: Molecular

SKU: M8529

$143.75 USD
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Coa

Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice.
Casnumber
1527503-11-2
Formula
C19H27N3O2
Mw
329.44
Psmiles
COC1=C(OCCCN2CCCC2)C=C3N=C(N)C4(CCC4)C3=C1
Purity
>98%
Solubility
DMSO: 10 mg/mL
Target synonyms
A366
A-366

A-366

$143.75 USD