Acetyl NF kB P65(K314/K315) (5G11) Mouse mAb

Acetyl NF kB P65(K314/K315) (5G11) Mouse mAb

Item number: EM1377
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Acetyl NF kB P65(K314/K315) (5G11) Mouse mAb

Acetyl NF kB P65(K314/K315) (5G11) Mouse mAb

$148.00

Acetyl NF kB P65(K314/K315) (5G11) Mouse mAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human, Mouse, Rat
Applications
IHC
Source
Mouse
Recommended dilutions
IHC 1:100-200
Immunogen
Synthetic Peptide
Isotype
IgG1
Clonality
Monoclonal
Concentration
1mg/mL
Observed band
65kDa
Geneid human
5970
Human swiss prot no
Q04206
Cellular localization
Cytoplasm, Nucleus
NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.

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