Actinin-α2/3 rabbit pAb

Actinin-α2/3 rabbit pAb

Item number: ES1594
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Actinin-α2/3 rabbit pAb

Actinin-α2/3 rabbit pAb

$148.00

Actinin-α2/3 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Actinin alpha-2/3. AA range:31-80
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
103kD
Geneid human
88/89
Human swiss prot no
P35609/Q08043
Cellular localization
Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],

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