AF-4 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES6253
Regular price
$148.00 USD
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Regular price
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
IHC;IF;WB;ELISA
Cellular localization
Nucleus .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
4299
Human swiss prot no
P51825
Immunogen
The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50
Isotype
IgG
Observed band
130kD
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
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Product Citations
Product Citations
More Info
More Info
AF-4 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
