Afatinib dimaleate

Vendor: Abmole

Type: Molecular

SKU: M5307

$80.50 USD
Shipping calculated at checkout.

Documents

Coa

Available in stock (500)

  • Customs clearance fees may apply
  • Worldwide shipping available.
For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Casnumber
850140-73-7
Formula
C24H25ClFN5O3.2C4H4O4
Mw
717.18
Psmiles
CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O
Purity
100.00%
Solubility
80 mg/mL in DMSO
Target synonyms
BIBW 2992MA2; BIBW2992; Afatinib
Afatinib dimaleate

Afatinib dimaleate

$80.50 USD