AIRE-1 (phospho Ser156) rabbit pAb

AIRE-1 (phospho Ser156) rabbit pAb

Item number: ES5771
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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AIRE-1 (phospho Ser156) rabbit pAb

AIRE-1 (phospho Ser156) rabbit pAb

$148.00

AIRE-1 (phospho Ser156) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human AIRE around the phosphorylation site of Ser156. AA range:126-175
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
50kD
Geneid human
326
Human swiss prot no
O43918
Cellular localization
Nucleus . Cytoplasm . Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083). .
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012],

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