ALK (Phospho-Tyr1586) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES18391
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
IHC;IF;WB
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
238
Human swiss prot no
Q9UM73
Immunogen
Synthesized peptide derived from human ALK (Phospho-Tyr1586)
Isotype
IgG
Observed band
150-240kD
Product weight
0.005kg
Reactivity
Human; Mouse
Recommended dilutions
IHC-p 1:50-200, WB 1:500-2000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome
Documents
Documents
Documents
Product Citations
Product Citations
More Info
More Info
ALK (Phospho-Tyr1586) rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
