ALK (Phospho-Tyr1586) rabbit pAb

Item number: ES18391
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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ALK (Phospho-Tyr1586) rabbit pAb

$148.00

ALK (Phospho-Tyr1586) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human; Mouse
Applications
IHC;IF;WB
Source
Rabbit
Recommended dilutions
IHC-p 1:50-200, WB 1:500-2000
Immunogen
Synthesized peptide derived from human ALK (Phospho-Tyr1586)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
150-240kD
Geneid human
238
Human swiss prot no
Q9UM73
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. .
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome

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