Almonertinib mesylate

Vendor: Abmole

Type: Molecular

SKU: M43838

$460.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Almonertinib mesylate is an orally active, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR sensitization and T790M resistance mutations, and also shows strong inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37, 0.29, and 0.21 nM, respectively. The IC50 of T790M/Del19 was 0.37, 0.29 and 0.21 nM, respectively, but the inhibitory effect on wild-type was weaker, with an IC50 of 3.39 nM. It can be used in the research of non-small cell lung cancer.
Casnumber
2134096-06-1
Formula
C31H39N7O5S
Mw
621.76
Psmiles
CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.CS(=O)(=O)O
Purity
>99.0%
Solubility
DMSO 31.25 mg/mL
Target synonyms
HS-10296 mesylate
Almonertinib mesylate

Almonertinib mesylate

$460.00 USD