Amphiphysin II rabbit pAb

Amphiphysin II rabbit pAb

Item number: ES4046
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Amphiphysin II rabbit pAb

Amphiphysin II rabbit pAb

$148.00

Amphiphysin II rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
Synthesized peptide derived from the C-terminal region of human Amphiphysin II.
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
64kD
Geneid human
274
Human swiss prot no
O00499
Cellular localization
[Isoform BIN1]: Nucleus . Cytoplasm . Endosome . Cell membrane, sarcolemma, T-tubule .; [Isoform IIA]: Cytoplasm .
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016],

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