Amyloid-β rabbit pAb
Amyloid-β rabbit pAb
Amyloid-β rabbit pAb

Amyloid-β rabbit pAb

Item number: ES8472
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Amyloid-β rabbit pAb

Amyloid-β rabbit pAb

$148.00

Amyloid-β rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
IF;WB;IHC;ELISA
Source
Rabbit
Recommended dilutions
IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
Immunogen
Synthesized peptide derived from Amyloid-β at AA range: 221-270
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
87kD
Geneid human
351
Human swiss prot no
P05067
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Membrane, clathrin-coated pit . Early endosome . Cytoplasmic vesicle . Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport ves
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014],

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