Amyloid-β rabbit pAb

Name: Amyloid-β rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES8472

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

IF;WB;IHC;ELISA

Cellular localization

Cell membrane ; Single-pass type I membrane protein . Membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Membrane, clathrin-coated pit . Early endosome . Cytoplasmic vesicle . Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport ves

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

351

Human swiss prot no

P05067

Immunogen

Synthesized peptide derived from Amyloid-β at AA range: 221-270

Isotype

IgG

Observed band

87kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300

Source

Rabbit

Storage

-20°C/1 year

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014],

Amyloid-β rabbit pAb

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