Anti-Avelumab Polyclonal Antibody
Regular price
$405.00 USD
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Regular price
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Available in stock (500)
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
ELISA
Clonality
Polyclonal
Form
Liquid
Host
Rabbit
Immunogen
Avelumab
Isotype
IgG
Notes
Antibodysystem can customize this product per customer's request including product size, buffer components, etc. For research use only.
Purification
Purified by antigen affinity column.
Specificity
The product is specific for Avelumab. This antibody serves as an excellent positive control for Avelumab immunogenicity (ADA) assays.
Storage
The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Target name
Rabbit polyclonal to Bavencio.
Background
Background
Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as "immune checkpoint inhibition.
Product Citations
Product Citations
More Info
More Info
Anti-Avelumab Polyclonal Antibody
Regular price
$405.00 USD
Sale price
Regular price
Unit price
/per
