APBB1 rabbit pAb

Item number: ES9386
Availability: In Stock
$148.00
$148.00
Please hurry! Only 100 left in stock

Documents

Size: 50μL
Subtotal: $148.00
10 customers are viewing this product

Customized & fast shipping

Terms and Conditions

Vareum

APBB1 rabbit pAb

$148.00

APBB1 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human protein . at AA range: 400-480
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
78kD
Geneid human
322
Human swiss prot no
O00213
Cellular localization
Cell membrane . Cytoplasm . Nucleus . Cell projection, growth cone . Nucleus speckle . Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). .
amyloid beta precursor protein binding family B member 1(APBB1) Homo sapiens The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012],

Related Products

Recently Viewed Products