ASLAN003

Vendor: Abmole

Type: Molecular

SKU: M20800

$86.25 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity

ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.

Casnumber
1035688-66-4
Formula
C19H14F2N2O3
Mw
356.32
Psmiles
COC1=CC=CC(=C1)C2=CC(=C(NC3=NC=CC=C3C(O)=O)C(=C2)F)F
Purity
>99%
Solubility
DMSO 71 mg/mL
Target synonyms
LAS 186323; Farudodstat
ASLAN003

ASLAN003

$86.25 USD