Ataxin-1 rabbit pAb

Ataxin-1 rabbit pAb

Item number: ES1718
Availability: In Stock
$148.00
$148.00
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Size: 50μL
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Ataxin-1 rabbit pAb

Ataxin-1 rabbit pAb

$148.00

Ataxin-1 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Ataxin 1. AA range:742-791
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
87kD
Geneid human
6310
Human swiss prot no
P54253
Cellular localization
Cytoplasm . Nucleus . Colocalizes with USP7 in the nucleus. .
ataxin 1(ATXN1) Homo sapiens The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted

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