Avapritinib (BLU-285)

Vendor: Abmole

Type: Molecular

SKU: M6202

$336.95 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM).
Casnumber
1703793-34-3
Formula
C26H27FN10
Mw
498.56
Psmiles
C[N]1C=C(C=N1)C2=C[N]3N=CN=C(N4CCN(CC4)C5=NC=C(C=N5)C(C)(N)C6=CC=C(F)C=C6)C3=C2
Purity
>99.0%
Solubility
DMSO ≥ 60 mg/mL
Target synonyms
Avapritinib
Avapritinib (BLU-285)

Avapritinib (BLU-285)

$336.95 USD