Bcr (phospho Tyr177) rabbit pAb

Name: Bcr (phospho Tyr177) rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES1274

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA

Cellular localization

Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, axon . Cell junction, synapse .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

613

Human swiss prot no

P11274

Immunogen

The antiserum was produced against synthesized peptide derived from human Bcr around the phosphorylation site of Tyr177. AA range:144-193

Isotype

IgG

Observed band

160kD

Product weight

0.005kg

Reactivity

Human;Mouse

Recommended dilutions

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Source

Rabbit

Storage

-20°C/1 year

Background

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Bcr (phospho Tyr177) rabbit pAb

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