BMH-21

Vendor: Abmole

Type: Molecular

SKU: M3892

$80.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo.
Casnumber
896705-16-1
Formula
C21H20N4O2
Mw
360.41
Psmiles
CN(C)CCNC(=O)C1=CC=CN2C(=O)C3=C(C=C4C=CC=CC4=C3)N=C12
Purity
>99.0%
Solubility
DMSO
BMH-21

BMH-21

$80.50 USD