Butein

Vendor: Abmole

Type: Molecular

SKU: M7630

$172.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator.
Casnumber
487-52-5
Formula
C15H12O5
Mw
272.25
Psmiles
OC1=CC(=C(C=C1)C(=O)\C=C\C2=CC(=C(O)C=C2)O)O
Purity
>99.0%
Solubility
DMSO ≥ 30 mg/mL
Target synonyms
2’,3,4,4’-tetrahydroxy Chalcone
Butein

Butein

$172.50 USD