Capmatinib dihydrochloride hydrate

Vendor: Abmole

Type: Molecular

SKU: M54609

$379.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Capmatinib dihydrochloride hydrate is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor (IC50=0.13 nM) that inhibits the phosphorylation of c-MET, as well as downstream effector proteins of the c-MET pathway, such as ERK1/2, AKT, FAK, In addition, Capmatinib dihydrochloride hydrate effectively inhibited the proliferation and migration of c-Met-dependent tumor cells, induced apoptosis, and demonstrated antitumor activity in a mouse model of tumor. Capmatinib dihydrochloride hydrate is mainly metabolized by CYP3A4 and aldehyde oxidase.
Casnumber
1865733-40-9
Formula
C23H21Cl2FN6O2
Mw
503.00
Psmiles
CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F.O.Cl.Cl
Purity
>99.0%
Solubility
DMSO 20.83 mg/mL; Water 3.33 mg/mL
Target synonyms
INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate
Capmatinib dihydrochloride hydrate

Capmatinib dihydrochloride hydrate

$379.50 USD