Caveolin-2 (phospho Tyr27) rabbit pAb

Caveolin-2 (phospho Tyr27) rabbit pAb

Item number: ES7828
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Caveolin-2 (phospho Tyr27) rabbit pAb

Caveolin-2 (phospho Tyr27) rabbit pAb

$148.00

Caveolin-2 (phospho Tyr27) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Caveolin 2 around the phosphorylation site of Tyr27. AA range:12-61
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
26kD
Geneid human
858
Human swiss prot no
P51636
Cellular localization
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. .
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011],

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