CDK12-IN-2

Vendor: Abmole

Type: Molecular

SKU: M31196

$667.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM). CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12.
Casnumber
2244987-03-7
Formula
C32H32N6O2
Mw
532.64
Psmiles
CN1C=C(C=CC1=O)C2=CC=C(C=C2)N(C3CCC(CC3)NC4=NC=C(C=C4)C#N)C(=O)NCC5=CC=CC=C5
Purity
≥99.0%
Solubility
DMSO 30 mg/mL (ultrasonic and warming)
CDK12-IN-2

CDK12-IN-2

$667.00 USD