CHIR 99021 trihydrochloride

Vendor: Abmole

Type: Molecular

SKU: M6594

$598.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator.
Casnumber
1782235-14-6
Formula
C22H18Cl2N8.3HCl
Mw
574.72
Psmiles
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl
Purity
>99.0%
Solubility
DMSO 28 mg/mL; Water 10 mg/mL
Target synonyms
Laduviglusib trihydrochloride; CT99021 trihydrochloride
CHIR 99021 trihydrochloride

CHIR 99021 trihydrochloride

$598.00 USD