Cyclosporine A

Vendor: Abmole

Type: Molecular

SKU: M1831

$57.50 USD
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Coa

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation.
Casnumber
59865-13-3
Formula
C62H111N11O12
Mw
1202.61
Psmiles
CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Purity
100.00%
Solubility
DMSO ≥ 45 mg/mL
Target synonyms
Ciclosporin A; CsA; Cyclosporin A; Antibiotic S 7481F1
Cyclosporine A

Cyclosporine A

$57.50 USD