CYFIP2 rabbit pAb

Name: CYFIP2 rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES8500

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA

Cellular localization

Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

26999

Human swiss prot no

Q96F07

Immunogen

Synthesized peptide derived from CYFIP2 at AA range: 1171-1220

Isotype

IgG

Observed band

150+45kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

WB 1:500-2000, ELISA 1:10000-20000

Source

Rabbit

Storage

-20°C/1 year

Background

disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,

CYFIP2 rabbit pAb

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