DAG1 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES8965
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;ELISA
Cellular localization
[Alpha-dystroglycan]: Secreted, extracellular space.; [Beta-dystroglycan]: Cell membrane ; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm . Cell membrane, sarcolemma . Cell junction, synapse, postsynaptic cell membrane . The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. Colocal
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
1605
Human swiss prot no
Q14118
Immunogen
Synthesized peptide derived from human protein . at AA range: 830-910
Isotype
IgG
Observed band
98kD
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
WB 1:500-2000 ELISA 1:5000-20000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015],
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More Info
More Info
DAG1 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per

