E7449

Vendor: Abmole

Type: Molecular

SKU: M5267

$759.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
Casnumber
1140964-99-3
Formula
C18H15N5O
Mw
317.34
Psmiles
O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5
Purity
>98%
Solubility
4 mg/mL in DMSO
Target synonyms
Stenoparib; 2X-121; MGI25036
E7449

E7449

$759.00 USD