Edicotinib

Vendor: Abmole

Type: Molecular

SKU: M10937

$1,035.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Edicotinib (JNJ-40346527) is a potent, selective, blood-brain permeable and orally active CSF-1R inhibitor.IC50 3.2 nM. Edicotinib has less inhibitory effect on KIT and FLT3,IC50 The values are 20 nM and 190 nM, respectively. Edicotinib inhibits the expansion of microglia, weakens the proliferation of microglia and neurodegenerative degeneration. Edicotinib can be used in the study of Alzheimer's disease and rheumatoid arthritis.
Casnumber
1142363-52-7
Formula
C27H35N5O2
Mw
461.6
Psmiles
CC1(C)CCC(=CC1)C2=NC(=CC=C2NC(=O)C3=NC=C([NH]3)C#N)C4CC(C)(C)OC(C)(C)C4
Purity
>99%
Solubility
DMSO ≥ 10 mg/mL
Target synonyms
JNJ-40346527; JNJ-527
Edicotinib

Edicotinib

$1,035.00 USD