FADD (phospho Ser191) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES4391
Regular price
$148.00 USD
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Regular price
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;IHC;IF;ELISA
Clonality
Polyclonal
Concentration
1 mg/ml
Immunogen
The antiserum was produced against synthesized peptide derived from mouse FADD around the phosphorylation site of Ser191. AA range:157-206
Isotype
IgG
Observed band
25kD
Product weight
0.005kg
Reactivity
Mouse
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The Fas associated via death domain encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
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Product Citations
Product Citations
More Info
More Info
FADD (phospho Ser191) rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
