Fludarabine

Vendor: Abmole

Type: Molecular

SKU: M2028

$69.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression.
Casnumber
21679-14-1
Formula
C10H12FN5O4
Mw
285.23
Psmiles
NC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)F
Purity
100.00%
Solubility
DMSO 27 mg/mL
Target synonyms
NSC 118218; Fludarabinum; F-ara-A
Fludarabine

Fludarabine

$69.00 USD