Hydroxyurea
DNA replication inhibitor causing deoxyribonucleotide depletion CH4N2O2=76.05 Hydroxyurea is an anti-neoplastic which inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of...
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DNA replication inhibitor causing deoxyribonucleotide depletion
CH4N2O2=76.05
Hydroxyurea is an anti-neoplastic which inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Specifications |
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| Appearance | White Crystalline Powder |
| Content by HPLC | >97.5 |
| Water | >0.5% |
| Related substances | >0.2% |
| Residue on ignition | >0.1% |
| Heavy metals | >10ppm |
| Residue on ignition | >0.1% |
Store at 2 - 8°C in dark, dry place
CAS 127-07-1
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