GNF4877

Vendor: Abmole

Type: Molecular

SKU: M14889

$920.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells).
Casnumber
2041073-22-5
Formula
C25H27FN6O4
Mw
494.52
Psmiles
CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCCC(C4)C(=O)O)N
Purity
>99%
Solubility
DMSO 4 mg/mL (ultrasonic and warming)
GNF4877

GNF4877

$920.00 USD