GS143

Vendor: Abmole

Type: Molecular

SKU: M6766

$207.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
GS143 is a β-TrCP1 ligase inhibitor. GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit proteasome activity.
Casnumber
916232-21-8
Formula
C28H19FN2O4
Mw
466.46
Psmiles
C1=CC=C(C=C1)CC2=NN(C(=O)C2=CC3=CC=C(O3)C4=CC=CC=C4F)C5=CC=C(C=C5)C(=O)O
Purity
>99.0%
Solubility
DMSO 35 mg/mL
Target synonyms
GS-143
GS143

GS143

$207.00 USD