GSK-J4 hydrochloride

Vendor: Abmole

Type: Molecular

SKU: M2731

$135.70 USD
Shipping calculated at checkout.

Documents

Coa

Available in stock (500)

  • Customs clearance fees may apply
  • Worldwide shipping available.
For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 hydrochloride is a cell permeable procompound of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.
Casnumber
1797983-09-5
Formula
C24H27N5O2.HCl
Mw
453.96
Psmiles
Cl.CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4
Purity
98.95%
Solubility
DMSO 50 mg/mL; Water ~2.5 mg/mL
GSK-J4 hydrochloride

GSK-J4 hydrochloride

$135.70 USD