GSK215

Vendor: Abmole

Type: Molecular

SKU: M29789

$701.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect.
Casnumber
2743427-26-9
Formula
C50H59F3N10O6S
Mw
985.13
Psmiles
CNC(=O)C1=C(NC2=CC(=NC=C2C(F)(F)F)NC3=C(OC)C=C(C=C3)N4CCN(CC4)CC(=O)NC(C(=O)N5CC(O)CC5C(=O)NC(C)C6=CC=C(C=C6)C7=C(C)N=CS7)C(C)(C)C)C=CC=C1
Purity
≥99.0%
Solubility
DMSO 250 mg/mL (ultrasonic)
GSK215

GSK215

$701.50 USD