GSK2193874

Vendor: Abmole

Type: Molecular

SKU: M10625

$147.20 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
Casnumber
1336960-13-4
Formula
C37H38BrF3N4O
Mw
691.62
Psmiles
FC(F)(F)C1=CC=CC(=C1)C2=NC3=CC(=CC=C3C(=C2CN4CCC(CC4)N5CCCCC5)C(=O)NC6(CC6)C7=CC=CC=C7)Br
Purity
>99%
Solubility
DMSO ≥ 70 mg/mL
Target synonyms
GSK-2193874; GSK2193874A
GSK2193874

GSK2193874

$147.20 USD