Guggulsterone

Vendor: Abmole

Type: Molecular

SKU: M13379

$131.10 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. Guggulsterone is a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
Casnumber
95975-55-6
Formula
C21H28O2
Mw
312.45
Psmiles
CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
Purity
>99%
Solubility
DMSO 20 mg/mL
Target synonyms
Z/E-Guggulsterone
Guggulsterone

Guggulsterone

$131.10 USD