HS-276

Vendor: Abmole

Type: Molecular

SKU: M29821

$281.75 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research.
Casnumber
2767422-72-8
Formula
C24H29N5O2
Mw
419.52
Psmiles
CCC[N]1C(=NC2=CC=C(CN3CCCCC3)C=C12)NC(=O)C4=CC=CC(=C4)C(N)=O
Purity
98.52%
Solubility
DMSO 50 mg/mL (ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
HS-276

HS-276

$281.75 USD