Inavolisib

Vendor: Abmole

Type: Molecular

SKU: M11405

$776.25 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Inavolisib (GDC-0077; RG6114) is a potential best-in-class, orally selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutants compared to wild-type PI3Kα. It can trigger the degradation of mutation-producing PIK3α.
Casnumber
2060571-02-8
Formula
C18H19F2N5O4
Mw
407.37
Psmiles
CC(NC1=CC=C2C(=C1)OCC[N]3C=C(N=C23)N4C(COC4=O)C(F)F)C(N)=O
Purity
>99%
Solubility
DMSO 90 mg/mL
Target synonyms
GDC-0077; RG6114；RO-7113755
Inavolisib

Inavolisib

$776.25 USD