INCB086550

Vendor: Abmole

Type: Molecular

SKU: M11354

$845.25 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
INCB086550 selectively inhibited PD-L1 with IC50 of 3.1 nM, 4.9 nM and 1.9 nM for human, rhesus monkey and rat pD-L1, respectively. INCB086550 could not inhibit the binding of PD-L2 to PD-1 at 10 μM. INCB086550 significantly inhibits the PD-1/PD-L1 signaling axis by binding to PD-L1 protein, leading to PD-L1 dimerization and internalization, and has good tumor suppressive effect in a variety of mouse tumor models.
Casnumber
2230911-59-6
Formula
C41H39N7O4
Mw
693.79
Psmiles
CC1=C(C=CC=C1NC2=NC=CC3=C2N=CC(=C3)CN4CCC(O)C4)C5=CC=CC(=C5C)C6=NC7=CC(=CC(=C7O6)C#N)CN8CCC(C8)C(O)=O
Purity
>98.0%
Solubility
Water ≥ 60 mg/mL
Target synonyms
PD-1/PD-L1-IN-8
INCB086550

INCB086550

$845.25 USD