INT-777

Vendor: Abmole

Type: Molecular

SKU: M9055

$569.25 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
INT-777 is a potent TGR5 agonist with EC50 of 0.82 μM. In animal models, INT-777 alleviates liver injury by activating TGR5, thereby increasing bile flow and reducing bile acid synthesis. TGR5 signalling mediated by INT-777 induces the release of GLP-1 (glucagon-like peptide-1), improving liver and pancreatic function in obese mice.
Casnumber
1199796-29-6
Formula
C27H46O5
Mw
450.65
Psmiles
CCC1C2CC(CCC2(C3CC(C4(C(C3C1O)CCC4C(C)CC(C)C(=O)O)C)O)C)O
Purity
98.29%
Solubility
DMSO: ≥ 25 mg/mL
Target synonyms
S-EMCA
INT-777

INT-777

$569.25 USD