JNJ-61432059

Vendor: Abmole

Type: Molecular

SKU: M29120

$506.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.
Casnumber
2035814-50-5
Formula
C25H22FN5O2
Mw
443.47
Psmiles
C1CN(CCC1O)C2=NC=CC3=C(C(=NN32)C4=CC=C(C=C4)F)C5=CC6=C(C=C5)NC(=O)C6
Purity
≥99.0%
Solubility
DMSO 50 mg/mL (ultrasonic)
JNJ-61432059

JNJ-61432059

$506.00 USD