JNK1/2/3 (phospho Thr183/Y185) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES1350
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
IF;WB;IHC;ELISA
Cellular localization
Cytoplasm . Nucleus . Cell junction, synapse . In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
5599/5601/5602
Human swiss prot no
P45983/P45984/P53779
Immunogen
The antiserum was produced against synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Thr183 and Tyr185. AA range:151-200
Isotype
IgG
Observed band
46+54kD
Product weight
0.005kg
Reactivity
Human;Mouse;Rat;Chicken/pig/fish(tested by our customer）
Recommended dilutions
IF: 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl
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Product Citations
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More Info
More Info
JNK1/2/3 (phospho Thr183/Y185) rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
