K252a

Vendor: Abmole

Type: Molecular

SKU: M2790

$258.75 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
Casnumber
99533-80-9
Formula
C27H21N3O5
Mw
467.47
Psmiles
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Purity
>99.0%
Solubility
DMSO 50 mg/mL (Need ultrasonic and warming)
Target synonyms
SF 2370; Antibiotic K-252a; Antibiotic SF 2370
K252a

K252a

$258.75 USD