Karyopherin α2 (Acetyl Lys22) rabbit pAb

Name: Karyopherin α2 (Acetyl Lys22) rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES20110

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA;IHC

Cellular localization

Cytoplasm . Nucleus .; Endoplasmic reticulum membrane. Golgi apparatus membrane . (Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

3838

Human swiss prot no

P52292

Immunogen

Synthesized peptide derived from human Karyopherin α2 (Acetyl Lys22)

Isotype

IgG

Observed band

60kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Source

Rabbit

Storage

-20°C/1 year

Background

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J re

Karyopherin α2 (Acetyl Lys22) rabbit pAb

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