KB02-JQ1

Vendor: Abmole

Type: Molecular

SKU: M29586

$414.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1.
Casnumber
2384184-44-3
Formula
C38H43Cl2N7O6S
Mw
796.76
Psmiles
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCOCCNC(=O)COC4=CC5=C(C=C4)N(CCC5)C(=O)CCl)C6=CC=C(C=C6)Cl)C
Purity
≥99.0%
Solubility
DMSO 200 mg/mL (ultrasonic)
KB02-JQ1

KB02-JQ1

$414.00 USD